The 23-year-old Kramer got a nasty blow to the head in a challenge with Argentina's Ezequiel Garay in the 18th minute and carried on after treatment before leaving the field looking dazed to make way for Andre Schuerrle.
Khedira, originally named in the starting eleven, suffered a calf muscle injury during the warm-up.
Some people criticised the decision to allow Kramer to play on for 13 minutes when he appeared to be concussed.
- Disease & Medical Conditions
- Ezequiel Garay