Nicknamed Baby Fed for the similarity of his playing style with that of 17-times grand slam champion Roger Federer, the Bulgarian 11th seed extended his winning run on grass to nine matches with a plethora of eye-catching shots.
He won his fourth career title in the traditional Wimbledon warm-up event at Queen's Club this month and has now followed up by booking his first quarter-final at the All England Club.
"First of all I'm happy that I'm in the quarter-final," he told reporters. "Just going to give credit to myself for that, but my job isn't over yet.
"You know, I don't want to stop here. Again, I hope there are going to be a lot more first times for me. I'm just aiming to be better and better every time."
His showdown against Murray, who has breezed through to the last eight without dropping a set, will be the truest indication yet of Dimitrov's progress.
"It's basically his home here ... He knows his way around the grass pretty good. He's a great mover," the Bulgarian said.
"I'm just going to play my game. I'm not going to step back. I just want to come out with my big game and play my aggressive tennis. I don't want to adjust to my opponent. I'm focusing on my game and what I can bring to the court."
The 23-year-old, a former junior winner at Wimbledon, combined lightning-quick movement with punishing groundstrokes, taking the first set with a forehand winner.
He continued to wow the crowd in the second set with a sumptuous half-volley winner from between his legs before a Mayer double fault gave Dimitrov the tiebreak for the set.
"I'm going to have another chance on Wednesday to challenge (the big four)," he added. "This is the position I want to be in at every slam and every tournament that they're on, whoever I'm playing. Those are the matches I want to play."
The Australian Open champion won is trying to conserve energy for a possible three matches in three days or five in seven should he reach his first Wimbledon final.
The Istomin encounter was originally scheduled for Saturday, but it was cancelled due to rain.
Wawrinka's coach Magnus Norman said playing five best-of-five set matches in seven days was "not humanly possible" and the 29-year-old Swiss player criticised the lack of consultation from the organisers.
"They just say what's going to be the schedule and that's it," he told reporters.
"Even if you want to talk to them, they're not going to change anything. They don't listen to the player, they just do what they think is good for them.
"Normally if the player starts to talk to the referee they never change the decision."
Wawrinka dominated the rallies with his superior groundstrokes, particularly his elegant one-handed backhand which looked in fine fettle.
He blazed away with 33 winners and converted four of his five break points as he reached the fourth round for the first time since 2009.
Wawrinka will next meet Feliciano Lopez for a place in the quarter-finals after the Spaniard beat American John Isner in four sets earlier on Monday.
"Me or Lopez have to play three matches in three days," said the Swiss. "It's terrible for the body.
"I was expecting them to move matches, move maybe the juniors or doubles."
Roger Federer's victory over Santiago Giraldo was the final match on Centre Court on Saturday, finishing at 7.13pm local time and leaving almost four hours to complete a match should it have started.
Wawrinka said he was surprised the Centre Court was not used to minimise disruption but praised the consistency of the officials.
"It was a tough decision to put one match (on Centre Court) because the good thing, if one thing they did well, they postponed my match and Isner v Lopez. They had to play both matches at the same time."
Results from the Wimbledon Men's Singles matches on Monday
1-Novak Djokovic (Serbia) beat 14-Jo-Wilfried Tsonga (France) 6-3 6-4 7-6(5)
11-Grigor Dimitrov (Bulgaria) beat Leonardo Mayer (Argentina) 6-4 7-6(6) 6-2
3-Andy Murray (Britain) beat 20-Kevin Anderson (South Africa) 6-4 6-3 7-6(6)
26-Marin Cilic (Croatia) beat Jeremy Chardy (France) 7-6(8) 6-4 6-4
19-Feliciano Lopez (Spain) beat 9-John Isner (U.S.) 6-7(8) 7-6(6) 7-6(3) 7-5
5-Stanislas Wawrinka (Switzerland) beat Denis Istomin (Uzbekistan) 6-3 6-3 6-4
- Sports & Recreation
- Roger Federer
- Denis Istomin
- Stanislas Wawrinka