Neither player has dropped a set but Nadal, in the second match on the Philippe Chatrier show court, should have little trouble setting up a meeting with either Spanish compatriot David Ferrer, the fifth seed, or South African Kevin Anderson, seeded 19.
Ferrer was beaten by Nadal in last year's final and the contest with Anderson is first on court Suzanne Lenglen.
The tightest contest may be between Simona Halep of Romania, the highest seed left in the women's draw at four, and 15th seed Sloane Stephens of the United States.
Both are in top form and the winner will be one of the favourites for the title.
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