Djokovic, a US Open finalist the last four years and winner in 2011, has also done his part to spoil America's grand slam party.
The Serb squashed another American hope on Saturday, pounding Querrey 6-3 6-2 6-2 to reach the fourth round for the eighth straight year while improving his record to a perfect 8-0 when facing U.S. opponents at Flushing Meadows.
Isner bombarded Philipp Kohlschreiber with 42 aces and never lost his serve but still dropped a 7-6(4) 4-6 7-6(2) 7-6(4) decision to the German.
Murray, the 2012 Open champion and 2013 Wimbledon winner, double-faulted to send his match to a fourth set, then swiftly took charge in a 6-1 7-5 4-6 6-2 win over Russian Andrey Kuznetsov.
That set up a clash against Tsonga, a 6-4 6-4 6-4 winner against Pablo Carreno Busta of Spain.
Raonic won three tiebreakers in a straight-sets win against Dominican Victor Estrella Burgos to set up a fourth-round duel with Japanese 10th seed Kei Nishikori, who beat 23rd seed Leonardo Mayer of Argentina in straight sets.
Australian Open winner Wawrinka was given a walkover into the fourth round when Blaz Kavcic of Slovenia defaulted because of a right foot injury.
Round three results
1-Novak Djokovic (Serbia) beat Sam Querrey (U.S.) 6-3 6-2 6-2
5-Milos Raonic (Canada) beat Victor Estrella (Dominican Republic) 7-6(5) 7-6(5) 7-6(3)
9-Jo-Wilfried Tsonga (France) beat Pablo Carreno (Spain) 6-4 6-4 6-4
8-Andy Murray (Britain) beat Andrey Kuznetsov (Russia) 6-1 7-5 4-6 6-2
10-Kei Nishikori (Japan) beat 23-Leonardo Mayer (Argentina) 6-4 6-2 6-3
22-Philipp Kohlschreiber (Germany) beat 13-John Isner (US) 7-6 4-6 7-6 7-6
- Sports & Recreation
- Andy Murray
- John Isner
- Milos Raonic
- Sam Querrey
- Jo-Wilfried Tsonga
- Philipp Kohlschreiber