Higgins was forced to sit and suffer as Trump ran in knocks of 100, 63, 110 and 68 to leave himself one short of a place in the quarter-finals in only 43 minutes.
But four-time world champion cut an inspired figure after the interval as breaks of 104, 89, 90, 124 and 63 helped the Scotsman stage a remarkable recovery when defeat beckoned.
It was perhaps Higgins' best performance of the season, and will give him real hope of making an impact when he bids for a fifth world title at the Crucible in April.
His reward is a meeting with defending champion Mark Allen, who continued his quest for a third straight World Open success with a 5-2 win over Ricky Walden.
Marco Fu made three centuries on his way to ousting world number one Neil Robertson from with a 5-4 win in the last 16.
The 2007 Grand Prix winner from Happy Valley in Hong Hong won the opening frame with a knock of 121 only to see Robertson claim the next two frames aided by runs of 61 and 127 - his 92nd century of the season.
Fu's response saw him reel off the next three frames courtesy of 127, 43, 52 and 114 to leave himself on the cusp of victory leading 4-2.
Robertson managed to eke out two scrappy frames to force the decider, but Fu held his nerve to win a re-spotted black-ball decider that lasted 49 minutes to reach the last eight.
His opponent will rue blowing the chance to see off Fu having missed a makeable pink to a centre bag that would have sealed his progress leading 49-36. Ful holed pink and black before nudging in a simple black for victory.
"I played well to go 4-2 up and felt strong," said Fu. "I lost a couple of scrappy frames and struggled with my safety. I was lucky Neil missed the pink in the last frame and I was able to take the chance in the end.
"I felt great among the balls but my safety and long potting were really bad. I have been consistent lately but if I want to win a tournament, consistent is not enough. I need to find more form in the latter stages of tournaments. Hopefully I can do that this week."
Fu will meet Mark Joyce for a spot in the semi-finals after the unheralded Englishman completed a 5-3 win over Norway's Kurtis Maflin.
Alan McManus continued to shows signs of his old form 20 years after he won the Masters at Wembley as he enjoyed a 5-1 win over Dominic Dale.
The doughty Scot shipped the first frame, but breaks of 101, 69 and 72 proved too much for Dale.
He faces the third seed and fellow former Masters holder Mark Selby on Friday afternoon in China after the Leicester player overcame Liang Wenbo 5-1 that included runs of 62, 135 and 131.
Shaun Murphy was a 5-4 winner over Ding Junhui with a highest break of only 57. He will face Graeme Dott in the last eight after the 2006 world champion contributed knocks of 88, 55, 88 and 92 in a 5-2 victory over Thailand's Thepchaiya Un-Nooh. who broke down on 134 in the third frame by missing a tricky pink with just the pink and black needed for a 147.
Last 16 results/draw
Order of play: Thursday, March 13 (best of nine frames)
Mark Selby (Eng) 5-1 Liang Wenbo (Chn)
Alan McManus (Sco) 5-1 Dominic Dale (Wal)
Mark Joyce (Eng) 5-3 Kurt Maflin (Nor)
Marco Fu (HK) 5-4 Neil Robertson (Aus)
Mark Allen (NI) 5-2 Ricky Walden (Eng)
John Higgins (Sco) 5-4 Judd Trump (Eng)
Thepchaiya Un-Nooh (Tha) 2-5 Graeme Dott (Sco)
Shaun Murphy (Eng) 5-4 Ding Junhui (Chn)
World Open quarter-finals
Order of play: Friday, March 14 (best of nine frames)
Mark Joyce (Eng) v Marco Fu (HK)
Mark Selby (Eng) v Alan McManus (Sco)
Mark Allen (NI) v John Higgins (Sco)
Graeme Dott (Sco) v Shaun Murphy (Sco)
- Sports & Recreation
- Marco Fu
- Neil Robertson
- John Higgins
- Mark Joyce
- Ricky Walden