SuperMario has still not recovered from a shoulder injury he sustained when falling awkwardly during a 1-0 Champions League defeat to Atletico Madrid.
He abandoned the training ground early on Saturday, confirming he won’t be able to take part in tonight’s Serie A clash with Juventus.
It also means Balotelli won’t be risked for Italy’s friendly against Spain on Wednesday evening.
Destro has played for Italy at Under-21 and senior level, but was out of action for eight months after a left knee injury sustained during the European Under-21 Championships in June 2013.
He turns 23 later this month and has scored six goals in 10 Serie A appearances for Roma this season.
Prandelli is also widely expected to call Parma defender Gabriel Paletta, who was raised in Argentina but has an Italian passport.
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- Sports & Recreation
- Cesare Prandelli
- Ciro Immobile