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England forward Theo Walcott could again be preferred in a central striker's role ahead of Olivier Giroud after scoring in the 5-2 win at Reading.
Manchester City striker Mario Balotelli will miss out after suffering from a virus. Captain and defender Vincent Kompany (groin) is hoping to prove his fitness while midfielders James Milner (hamstring) and Gareth Barry (suspension) return.
QPR goalkeeper Julio Cesar and right-back Jose Bosingwa will both miss out. The pair have sustained back injuries and will not travel to the north east, with midfielder Kieron Dyer also missing out through injury.
Sunderland boss Martin O'Neill will await the results of late fitness tests on a trio of key players before naming his team. Full-backs Phil Bardsley (knee), Danny Rose (ankle) and striker Steven Fletcher (back) have returned to light training, but are yet to prove they are ready to play.
Gareth Bale has recovered from his hamstring injury and is available, while Stoke midfielder Charlie Adam is set to miss the clash.
West Brom will be without suspended midfielder Youssouf Mulumbu; Norwich captain Grant Holt is doubtful because of a hamstring injury.
Everton will be without midfielder Marouane Fellaini as the Belgium international begins a three-match suspension.
Defender Jose Enrique returned to training this week after a hamstring injury and comes back into contention, while Nuri Sahin is fit after surgery on a broken nose.
Rafael has been ruled out. Shinji Kagawa (knee) and Nani (hamstring) are both still sidelined, but Jonny Evans is available after his own hamstring problem.
Ramires, John Obi Mikel and Gary Cahill all return from suspension, Daniel Sturridge is available for selection after his hamstring injury, but Ryan Bertrand is doubtful.