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Playmaker Philippe Coutinho is set to return to the starting line-up as Daniel Sturridge remains sidelined; Anthony Pilkington (hamstring), Robert Snodgrass (knee) and Ricky van Wolfswinkel (toe) miss out.
Phil Jones is suspended after picking up five yellow cards but Ryan Giggs is likely to start; Everton manager Roberto Martinez has no new injury worries ahead of the trip to Old Trafford, with Leighton Baines out.
Artur Boruc will miss the clash against Aston Villa because of a broken hand; Paul Lambert will check on striker Andreas Weimann's fitness.
Stoke defender Robert Huth will miss the clash with Cardiff and is set to be sidelined for at least three weeks; Craig Bellamy and Peter Odemwingie may be set for starting roles having been on the bench for Saturday's defeat against Arsenal.
John O'Shea will undergo a late fitness test; Chelsea manager Jose Mourinho will be without Brazilian duo David Luiz and Oscar.
Swansea remain without top scorer Wilfried Bony who will watch from the stands because of a hamstring injury; Alan Pardew has no fresh injury problems.
Fulham right-back Sascha Riether will return from a three-match suspension for new manager Rene Meulensteen's first game in charge; Emmanuel Adebayor is still struggling with a groin problem and is therefore a major doubt.
West Brom expect to have Zoltan Gera and Billy Jones available; Vincent Kompany has been named in Manchester City's squad for the visit to the Midlands