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All games KO at 19:45 unless otherwise stated.
Juan Mata is set to make his Manchester United debut against Cardiff at Old Trafford. The Bluebirds are poised to announce the new signings of Fabio from United and Kenwyne Jones from Stoke but neither are likely to play.
Norwich will again be without midfielder Jonny Howson (back) and centre-back Michael Turner (hamstring). Full-back Mathieu Debuchy returns after a three-match ban, but striker Papiss Cisse (back) and midfielder Gabriel Obertan (ankle) will miss out. Yohan Cabaye will not be part of the Newcastle squad as he is having a medical with PSG on Tuesday.
Victor Wanyama could return from a seven-week injury lay-off for Southampton, although Rickie Lambert is a doubt. Midfielders Aaron Ramsey (thigh) and Mikel Arteta (calf) and defender Thomas Vermaelen (knee) are all back training, although Wenger is not planning on using any of them from the start and Jack Wilshere is a doubt with an ankle problem.
Swansea should welcome back goalkeeper Michel Vorm and midfielder Nathan Dyer. Rene Meulensteen is expected to rotate his options once more after giving a number of first-team regulars a rest in Sunday's FA Cup draw at Sheffield United.
Defender Jonny Parr is expected be out for Crystal Palace while Jerome Thomas and Kagisho Dikgacoi are still suffering from calf problems and Jack Hunt (ankle) and Glenn Murray (knee) are out. Shane Long is set to make his Hull debut
Liverpool defender Mamadou Sakho (hamstring) is still two to three weeks away from fitness while Jon Flanagan is set to start after making his comeback as a substitute at the weekend after a month out. Everton manager Roberto Martinez will make a late call on whether to include loan signing Lacina Traore in his squad. Doubts persist over defensive quartet Phil Jagielka, Sylvain Distin, Antolin Alcaraz and Seamus Coleman.