David Moyes' side have already booked their place in the last 16 but require a point against the Ukrainian title winners to seal top spot in Group A and avoid most of Europe's heavyweights in next week's knock-out round draw.
After back-to-back home Premier League defeats, victory is important for United as they look to boost their flagging morale.
Former Everton boss Moyes is now trying to get as much as possible from his squad after they dropped to ninth in the top flight with the departure of Sir Alex Ferguson clearly having had a seismic effect.
"The players are hurting because they are used to winning," the United said.
"When we don't win that hurts. The expectancy is to win all the games. They'll respond in the right way.
"I take complete responsibilty for the results.
"Fortunately they have been good in the Champions League but not so good in the Premier League and I will take responsibilty for them as well.
"We've lacked a bit of good fortune which could have made all the difference."
"We've got roughly the same squad that was champions last year," Moyes said.
"We've not changed an awful lot in that period.
"I need to make sure I'm getting the best out of the players and we are performing as well as we possibly can.
"I do think we can play better but there were a lot of games last year where Manchester United didn't play particularly well and maybe, in a game like that, sneaked it with a goal."