Young Frenchman Helan netted in added time to help the Owls clinch a 2-0 home win over Charlton on Saturday before returning to parent club Manchester City at the end of his loan spell.
Manager Dave Jones is also set to be without veteran midfielder David Prutton who limped off injured in the 67th minute against the Addicks.
His replacement, Chris Lines, is expected to continue for the meeting with Dougie Freedman's Trotters as Wednesday go looking for their third win in a row.
And they may be boosted by the availability of striker Jay Bothroyd. He has missed the last two matches with an ankle problem but hopes to get in a full training session ahead of the game.
Towering defender Reda Johnson is set to play at the Reebok Stadium after a return to the team on Saturday. He had been out since mid-September with a foot injury.
And Rhys McCabe will continue in midfield, boosted by netting his first senior goal for the Owls against Charlton.
Defender Jose Semedo is missing, though, due to a cut on his knee but Jermaine Johnson, an unused substitute on Saturday, hopes to get game time.