The Uruguayan striker scored four goals in Liverpool's 5-1 destruction of Norwich at Anfield on Wednesday, bringing his total to 11 goals, including three hat-tricks, in just four matches against Norwich.
Hughton wants his defenders, in particular, to learn from the experience and demonstrate they have done so against West Brom, who lie just one point above them in the Premier League, at the Hawthorns on Saturday.
Hughton, whose side were also hammered 7-0 by Manchester City last month, said: "We were up against a world class player but if you allow him space and time he can hurt you and he hurt us. It is one we have to learn from and move on from.
"The stats speak for themselves. We are on the back of a big defeat at Manchester and at Liverpool. We have to defend better as a team. The individual errors are costing us.
"We are hurting and I certainly want to see a reaction. We have been able to react in the right way this season. I want to see a performance which gives us a good chance of winning the game.
"It's an opportunity for us. You want the next game to come around a little bit quicker, especially on the back of the defeat we had. It's a game we must look forward to."
Hughton has no new injury worries following the Liverpool game but Norwich are still missing key personnel such as striker Ricky van Wolfswinkel, Anthony Pilkington, Robert Snodgrass and Alexander Tettey through injury.
They also possess the joint-worst defence in the Premier League, having conceded 28 goals along with bottom-placed Sunderland.
Hughton, whose side also face the three sides currently occupying the relegation places in the next month - Fulham, Crystal Palace and Sunderland - said: "The stats don't lie and our performances and results have not been good enough away from home.
"You want big characters in your squad and team. You look for that when you are on the back of a bad run.
"We have played a lot of the top teams and found it quite difficult but we are still in touching distance and some of the teams being spoken about in good terms are only a point or two in front of us."
If Norwich are to steer clear of being embroiled in a season-long battle for survival, then away form must improve, with 18 defeats from the 26 Premier League matches since Hughton took charge.
That is why the West Brom fixture, coming so soon after the Anfield fiasco, could act as a line in the sand for Hughton's side.
"It's not just about defenders, it's about the team," Hughton said.
"We've said what we had to say and you have to get that out of the way as quickly as possible and stick to a game plan to beat West Brom on Saturday.
"It will be a tough test but we have got to be grateful this game has come around as quickly as it has. It gives us an opportunity to right some wrongs. The only way to bounce back is to work hard and believe in yourself."