Sevilla, who won back-to-back UEFA Cups during the 2005/06 and 2006/07 season, will take on fellow Spaniards Valencia, who have one European success to their name – a UEFA Cup triumph ten years ago.
Unai Emery's in-form Sevilla side coasted into the semi-finals with a 4-1 win over Porto at the Ramon Sanchez Pizjuan stadium to progress 4-2 on aggregate and secure the coach a tie against his former club.
Emery led Valencia to three top-three finishes in the Primera Division before leaving the Mestalla in 2012.
Valencia booked their place in the semi-finals with a remarkable comeback to beat Basle 5-0 on Thursday, overturning a 3-0 first-leg deficit.
In the competition’s other last-four clash, Benfica, who have never won Europe’s second-most prestigious cup competition – despite winning the European Cup on two separate occasions – take on Italian giants Juventus, who will be vying for their fourth UEFA Cup/Europa League crown.
Both sides remain undefeated in their six matches since joining the competition at the knockout stage and whoever advances will meet the winners of the other semi-final between Spanish sides Sevilla and Valencia.
It is the first time the Spanish rivals have met in European competition while Juventus have faced Benfica twice before, with the Portuguese winning a European Cup semi-final in 1968 but losing to the Italians in a UEFA Cup quarter-final 21 years ago.
The first legs of the semi-finals are to be played on April 24-25 and the second legs on May 1-2.
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