Arsenal's 19-year-old defender Calum Chambers will be joined by Jack Colback of Newcastle United, Tottenham Hotspur's Danny Rose and Aston Villa's Fabian Delph, all aged 24, as the new faces in the 22-man squad.
"It will be exciting but there will be some anxious moments to see how these players step up," Hodgson told a news conference on Thursday.
"We've been a bit unlucky in our first qualifier, it is arguably our hardest one (Switzerland away) and these players may not get the soft introduction they may have had.
"I don't think there is any reason for intrepidation. With these players we are bringing into the squad, and don't forget there's no Theo Walcott, Ross Barkley or Adam Lallana, I see no reason for us to be fearful."
The squad in full:
Midfielders: Jack Colback (Newcastle United), Fabian Delph (Aston Villa), Jordan Henderson (Liverpool), James Milner (Manchester City), Alex Oxlade-Chamberlain (Arsenal) Raheem Sterling (Liverpool), Andros Townsend (Tottenham Hotspur), Jack Wilshere (Arsenal)
- Sports & Recreation
- Tottenham Hotspur
- Aston Villa
- Danny Rose
- Fabian Delph
- Calum Chambers
- Manchester United