Asked if he was ready to run for UCI president in 2013, LeMond, who won the Tour in 1986, 89 and 90, told the French daily Le Monde on Monday: "Yes I am ready. I was asked to and I said yes.
"With the Change Cycling Now movement, we want to change cycling. It is now or never."
LeMond is part of Change Cycling Now, a lobby group set up by former riders, journalists and a sponsor who look to radically change the way the sport is ruled in the wake of the Lance Armstrong scandal.
The American has been stripped of his seven Tour de France titles after the United States Anti-Doping Agency accused him of being at the centre of an organised doping conspiracy.
LeMond said: "I would do whatever I can to help change the sport. I would love to be part of the process to help change cycling."
Current UCI president Pat McQuaid has said he is seeking a third term.