The German told Handelsblatt: "I will remain active in the peloton, but no longer with Lampre. You have kept me happy in the team, but it's once again time for a change. I think I need this stimulus."
Alessandro Petacchi's lead-out man, 38, claimed just one victory during his time at Lampre - the 2010 Giro di Sardegna.
Hondo has been linked with RadioShack-Nissan, who have lost number one sprinter Daniele Bennati for next year.