It came down to a battle between Drujon and Rémi Pauriol (Sojasun), Romain Bardet and Sylvain Georges (both AG2R La Mondiale) and it was the 30-year-old who got the win.
The quartet were part of a bigger leading pack that formed on the biggest climb of the day – the Rocher de Sampzon - with 17km to go and they then sprung clear at the top of the climb.
Drujon won the race for the line ahead of last year's winner Pauriol with Bardet in third.
French legend Thomas Voeckler (Europcar) did try and chase down the final four with a solo attack near the end but he was swallowed up and had to settle for 11th.
Two of Sunday's other races on the calendar – the Kuurne-Brussel-Kuurne and Città di Lugano - were both cancelled due to inclement weather.