Pacquiao was far from his career peak at the MGM Grand Garden Arena, but stylishly stepped up through the gears from the seventh round onwards while the previously-unbeaten Bradley struggled to stick to a gameplan after a strong start to the contest.
Regardless of the outcome or just how strong individual performances were, however, the chemistry between the two combatants once again struck gold as they produced an even more entertaining scrap than their dramatic June 2012 encounter.
Pacquiao had also appeared to secured a win two years ago, only for the judges to award it to the American via split decision.
This time around, 'Pac-Man' started hot, dazzling the defending titlist in the second round after an even opener before keeping the pressure on in round three courtesy of some vintage fast footwork.
Rounds four five and six saw Bradley start to find his range, however, and several stiff rights rocked the Filipino at various intervals, leaving the fight finely poised at the halfway stage.
It was from here that Pacquiao and his corner began to pull away, while 'Desert Storm' found himself consistently reliant on swinging wild overhand counters and taunting his opponent after each lightning Manny flurry.
Come the final two rounds, Pacquiao had asserted himself to the point that Bradley would require a finish to retain his title - but all he could manage was a slight improvement as the two closed their second encounter with a bang.
At the end of the final hard-hitting six minutes, both men raised their hands - though it was clear from Bradley's body language that he knew Pacquiao had evened the score.
Pacquiao won it on all three judges' scorecards - 118-110 and two at 116-112 - with Eurosport also rating the contest as a four-round Pacquiao win.
On the undercard, three entertaining bouts also all ended in a unanimous decision victory. Ray Beltran claimed NABO lightweight title in the chief support bout against late replacement Arash Usmanee in what was additionally a world title eliminator.
Jessie Vargas claimed a very tight points victory over Khabib Allakhverdiev for the WBA junior welterweight championship, taking all three judges’ scorecards after 12 rounds in a physical, bloody, back-and-forth battle of unbeaten boxers.
And Bryan Vazquez outclassed Jose Felix Jr in a scrappy but engaging opener on the main televised card. Vazquez retained the WBA interim super featherweight championship with a unanimous decision win.
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