The unbeaten Garcia (34-0, 29 knockouts) inflicted just the second defeat of Burgos's career at Madison Square Garden, with judges marking it 118-110, 118-110, 119-109 in favour of the champion.
Garcia had a slow start, being put under severe pressure by Burgos in round two, but thereafter Garcia completely dominated, with the softly spoken American being mentioned as a possible opponent for the winner of the Manny Pacquiao v Timothy Bradley rematch in April.
Lamont Peterson beat Dierry Jean on points to retain his IBF junior welterweight belt in Washington DC, erasing memories of his drubbing by Lucas Matthysse in a non-title bout last May.
Peterson imposed himself on Jean throughout, with judges scoring it 118-110, 116-112 and 115-113 in Peterson's favour, improving his record to 32-2-1.
Jean had been unbeaten going into the bout, but never looked up to the standard of Peterson, who now has his eyes on a potential unifying bout with WBC and WBA titlist Danny Garcia.
Marco Huck knocked out Firat Arslan in Germany to defend his WBO cruiserweight title.
Veteran Arslan stormed into the fight looking desperate to grab what may end up being his last chance to win a world title, but his 43 years began to show as the 29-year-old Huck outgunned and outmoved him before laying him out in the sixth round.