The 27-year-old, the World Cup champion elect after six wins from eight of nine rounds so far this season, dominated from start to finish at the Switzerland track.
She took the lead with her first run then maintained it on the second and third before posting the fastest time of all with her fourth and final effort for a comfortable winning margin.
Humphries, the Olympic champion from Vancouver 2010, beat American Elana Meyers by 0.68seconds, a massive margin in bobsleigh, with multiple world champion Sandra Kiriasis claiming bronze.
And, with Humphries now toasting two world titles, an Olympic title and soon to be a first World Cup title, she reflected on a remarkable run.
"It has been a really great three years," said Humphries. "There have been ups and downs but I am continuing on the success from Vancouver and I will work hard continue it next year."
Humphries clocked 1:07.03minutes with her fourth and final run, the fastest of the entire competition, to win by almost seven tenths of a second however the gap between second and sixth was far tighter.
After a poor third run, Anja Schneiderheinze laid down the marker by recording 1:07.04 but that was only good enough for fifth overall as Meyers and Kiriasis completed the podium.
Meyers's overall time of 4:30.99 was just 0.02 better than that of Kiriasis while Cathleen Martini was fourth just 0.07 further adrift before another gap of 0.02 before Schneiderheinze in fifth.
And Esme Kamphuis rounded out a top six that was 1.46 away from the rest of the field just 0.06 back on Schneiderheinze who was the third German pilot home.
Meanwhile British pilot Paula Walker, who is battling to limit damage to a knee injury in order to be fit for the World Cup finale at the 2014 Olympic track in Sochi, was 14th.
That was seven places down on her finish last year while British teammate Victoria Olaoye was 17th and junior world bronze medallist Mica McNeill was 20th.