The 31-year-old Norwegian won the 15km women's individual event in a time of 44:33.5 minutes, 1:03.2 clear of her nearest rival, after a perfect shooting display.
Berger is the reigning Olympic and world champion in the individual discipline and in the first race of the season since the retirement of the all-conquering Magdalena Neuner she blew the competition away.
Belarus' Darya Domracheva, many people's favourite for this season's World Cup title after finishing second overall behind Neuner last campaign, had to settle for second.
Third was Switzerland's Selina Gasparin, a full three minutes down on Berger's superb effort.
Finland's Kaisa Makarainen, the World Cup champion from the 2010/11 season, had an off day at the shooting range with four misses relegating her down to sixth.