Tony Parker had 31 points and 10 assists, Tim Duncan scored 30 points while Manu Ginobili added 23 off the bench in an outburst that was reminiscent of performances when the Spurs won four titles from 1999-2007.
San Antonio snatched a 41-29 lead after the first quarter then had to hold off Houston as the Rockets' James Harden (33 points) and Jeremy Lin (21) helped them pull close in the second and third quarters before losing ground in the final period as their five-game win streak was snapped.
San Antonio (23-8) led just 101-97 early in the fourth before going on an 11-0 run.
Houston shot 52 percent from the field but were outdone by the deadly accurate Spurs who made 57 percent of their shots and knocked down 12 three-pointers. (Writing by Jahmal Corner in Los Angeles; Editing by Greg Stutchbury)