He and a female Arsenal supporter held up the paper note to camera that read: "What do we think of Tottenham? S***. And what do we think of s***? Tottenham"
The supporter later posted the picture on Twitter, where it was widely shared.
Cazorla said he was unaware of what was written and said sorry for the message.
The Spaniard wrote on Twitter: "Our apoligizes to the Totenham fans, we couldn't see the paper. #alwaysfootballalwaysrespect"
— Santi Cazorla (@19SCazorla) January 20, 2014
Cazorla signed the brief social media note on his behalf and on the behalf of Robert Pires, the former Arsenal winger, who also appeared in the photo.
It capped a bad end to a great few days for the in-form Spaniard.
Cazorla was the hero of the day on Saturday as he scored both goal in Arsenal 2-0 victory over Fulham that kept them top of the league.
He also recently scored in Arsenal's FA Cup victory over…Tottenham!