Manchester United v Newcastle United
Darren Fletcher is expected to make his first start in 10 months against Newcastle. Fletcher is on the comeback trail as he tries to combat a chronic bowel problem. Striker Wayne Rooney , who has not played for a month after suffering a severely gashed thigh against Fulham, could also return against the Magpies. However, centre-back Nemanja Vidic is expected to be out for two months after undergoing knee surgery. New-boy Angelo Henriquez - who is not available for Champions League games as United did not receive international clearance in time for him to be registered - is available, whilst Nick Powell and Alex Buttner are also amongst those set to make Sir Alex Ferguson's starting line-up.
Newcastle's Fabricio Coloccini and Cheick Tiote could both return for the trip to Old Trafford. Argentina defender Coloccini has recovered from a hamstring injury after being allowed to stay with his national side's medical team, and Ivory Coast midfielder Tiote has finally shaken off a calf problem. Manager Alan Pardew is again likely to rest several of his big names and has hinted Rob Elliot could get another chance in goal, while first-choice goalkeeper Tim Krul (elbow) is hoping to be given the go-ahead to resume training when he sees his specialist on Wednesday and full-back Danny Simpson (hamstring) could re-join his team-mates later this week.
Queens Park Rangers v Reading
Defender Anton Ferdinand will miss out due to a hamstring injury. Jose Bosingwa suffered a hamstring problem against Tottenham on Sunday and is unavailable, while Armand Traore (leg), Andy Johnson (knee) and Fabio (hamstring) are also absent. Stephane Mbia and Adel Taarabt are fit after recovering from their respective groin and hamstring problems, while Kieron Dyer may start his first match since the opening day of last season after impressing as an early substitute at White Hart Lane.
Reading boss Brian McDermott will look to give some of his squad players a run out at Loftus Road. Mali winger Jimmy Kebe could make his first appearance of the season after recovering from a hamstring problem and coming through a practice match unscathed. Jason Roberts (calf) and Adam Federici (knee) are the two players unavailable to McDermott although the former could return at the weekend.
Norwich City v Doncaster Rovers
Norwich centre back Sebastien Bassong is a major doubt after hurting his hamstring during the Premier League loss at Newcastle. Michael Turner, who made his debut off the bench in that match, could replace the Cameroon stopper, while midfielders Elliott Bennett and Jacob Butterfield may also start.
Doncaster midfielder Martin Woods is a doubt after suffering a twisted knee in Saturday's draw with Stevenage. Defender Rob Jones is one booking from a suspension so may be rested with the league in mind.
Arsenal v Coventry City
Arsenal manager Arsene Wenger will hand some of his fringe players the chance to impress. Theo Walcott, Andre Santos, Johan Djourou, Andrei Arshavin and Francis Coquelin are all in contention to start against the Sky Blues. Striker Olivier Giroud could also be handed a chance to break his scoring drought, while youngsters Ignasi Miquel and Nico Yennaris are also expected to feature. Midfielder Emmanuel Frimpong may be included in the squad after recovering from a serious knee injury.
New signing James Bailey is in contention for his debut as Coventry make the trip to the Emirates Stadium. The midfielder arrived from Derby on Tuesday on a three-month loan deal and could well start at the Emirates, although new boss Mark Robins has lost the service of two loanees. Midfielder Conor Henderson arrived last Friday from the Gunners and is ineligible to play against his parent club, while striker David McGoldrick is cup-tied having featured for Nottingham Forest earlier in the competition. Steven Jennings will be assessed but is expected to be fit having being forced off in the first half of Saturday's 2-1 defeat to Carlisle. The loss - Robins' first game at the helm - was the Sky Blues' fourth successive defeat and left them winless from their opening eight league matches.
Carlisle United v Tottenham Hotspur
Joe Garner, on loan from Watford, is cup-tied and misses out for Carlisle. The striker featured in an earlier round for Watford and will therefore be ineligible for selection. Fellow loanee Kallum Higginbotham is available, however, and could replace Garner to start alongside former Huddersfield team-mate Danny Cadamarteri in attack. Midfielder Paul Thirlwell (concussion) and defender Danny Livesey (head wound) were both forced off late on in Saturday's 2-1 victory at Coventry but should be fit. Striker Lee Miller (knee) remains a long-term absentee.
Tottenham will make a number of changes from the team that beat QPR for the trip to Brunton Park. Tom Huddlestone, Michael Dawson, Steven Caulker and Andros Townsend are likely to make their first starts of the season while Gareth Bale, Brad Friedel and William Gallas will probably be rested. Emmanuel Adebayor (hamstring), Kyle Naughton (foot), Scott Parker (Achilles), Jake Livermore (groin), Benoit Assou-Ekotto and Younes Kaboul (both knee) are out, but Heurelho Gomes has recovered from an ankle problem and will travel.
West Bromwich Albion v Liverpool
West Brom midfielder James Morrison is the main new injury concern against holders Liverpool at the Hawthorns. The Scotland international suffered a hamstring injury during the weekend win over Reading and is rated "doubtful" by Baggies assistant head coach Keith Downing. Striker Peter Odemwingie (suspended) and winger Jerome Thomas (knee) are again ruled out. They are expected to make some changes from the team that beat Reading, with Shane Long pushing for a start, although Romelu Lukaku will take some dislodging at the head of the Baggies attack. Graham Dorrans, Gonzalo Jara, Markus Rosenberg and Boaz Myhill could all come into the XI.
Manager Brendan Rodgers is set to make changes as Liverpool begin their League Cup defence. Defenders Martin Kelly and Daniel Agger (both knee) were injured in Sunday's defeat to Manchester United and have been ruled out - the former for several months - while forward Fabio Borini is unlikely to be risked after sustaining an ankle problem. Brad Jones will replace Jose Reina in goal while some other fringe players will be given a chance.