The Frenchman partners Briton Leon Camier at the team, which had verbally agreed a deal with another Frenchman Sylvain Guintoli for 2013 before he reneged on that to explore other options.
"I am really excited to be joining the FIXI Crescent Suzuki team," said Cluzel.
"It is a big step in my career, but one that I am very happy to take. When I was given the option to work with Suzuki in World Superbikes, I did not need to think about it twice.
"I cannot wait to start work and I am also really pleased to be working with an English team."
Cluzel took four race wins in WSS after joining Honda from Moto2 outfit Suter, where he raced for two seasons and won the British GP in 2010.
The season before in 2009 was his 'big bike' debut with Aprilia in the quarter-litre World Championship.
FIXI Crescent Suzuki principal Paul Denning said Cluzel's experience will be vital in WSBK.
"Securing Leon's team-mate for 2013 hasn't exactly been the smoothest process, but in the end we couldn't be happier with the result," he said.
"Jules is young, fast and aggressive and has shown that he can adapt to new bikes and new championships very quickly. His 250GP and Moto2 experience provides an understanding and feeling for stiffer, less forgiving 'race-bikes' which the WSBK machines have developed into, and we anticipate a quick transition to the GSX-R.
"Any rider who has won a Moto2 race - and finished ahead of riders like Stefan Bradl and Scott Redding in the Championship standings - and then come to such a competitive series as World Supersport and just missed out on becoming champion in his first year, clearly has a great talent."
Denning had another dig at Guintoli, who is yet to secure a ride elsewhere for 2013.
"Importantly, Jules has shown his commitment and is very excited to be with FIXI Crescent Suzuki in WSBK for 2013 - it's nice to create a partnership where both sides are equally committed and share the same targets," he said.