The 27-year-old won the men's 5,000m at the Adler Arena on Saturday and skates in the 10,000m on Tuesday - an event he thought he had won four years ago only to be disqualified for an incorrect lane change after easily clocking the best time.
"A very tough decision, but I have decided not to skate the 1,500m race. This to stay focused on my 10,000m and the team pursuit event," Kramer posted on his Twitter page (@SvenKramer86) on Wednesday.
Jan Blokhuijsen, who finished second to Kramer in the 5,000m, will take his place in the race.
Blokhuijsen had contemplated flying home after the opening race on Saturday and returning for the team pursuit which starts on Feb. 21.
"It is great to have another goal between now and the team pursuit," he said.
The Dutch have won three of the first four speed skating golds in Sochi and completed two medal sweeps in the men's 5,000m and the 500m.