Indian billiards star Advani, who beat Sam Baird 6-2 on Tuesday, took the deciding frame to win 6-5 and deny fans the chance of White playing old adversary Steve Davis at the last 64 stage of snooker’s second biggest event.
White has made the quarter final of a European PTC event this season but has failed to qualify for a major TV tournament and is down at 56 in the rankings.
There were contrasting fortunes for two former Crucible semi-finalists. Andy Hicks had a 147 maximum in his 6-2 win over Daniel Wells but Alan McManus went down 6-2 to China's Tian Pengfei.
Luca Brecel, the 17-year-old Belgian who became the youngest ever player to qualify for the World Championship this year, defeated Peter Lines 6-4 and needs two more wins to reach the televised last 32 at the York Barbican.
Qualifying Round Two results:
Rod Lawler 6-5 Dechawat Poomjaeng
T Thirapongpaiboon 6-5 Alfie Burden
Craig Steadman 6-4 Mike Dunn
Yu Delu 6-4 Paul S Davison
Anthony McGill 6- 2 Zhang Anda
Jimmy Robertson 6-5 Michael Wasley
James Wattana 6-4 Jamie O'Neill
Ian Burns 6-3 Kurt Maflin
Cao Yupeng 6-3 Liam Highfield
Thepchaiya Un-Nooh 6-1 Barry Pinches
Adam Duffy 6-2 Fraser Patrick
Chen Zhe 6-4 Aditya Mehta
Pankaj Advani 6-5 Jimmy White
Tian Pengfei 6-2 Alan McManus
Andy Hicks 6-2 Daniel Wells
Luca Brecel 6-4 Peter Lines