Hawkins secured his ninth successive victory in the tournament early on Sunday as a last second pink saw him edge Michael White 43-39.
However, despite an early break of 37 he crashed in the quarters to Maguire who built a decisive half century off a quality red.
Maguire is joined in the semi-final finals by Martin Gould, Mark Allen and Michael Holt.
Andrew Higginson 28-45 Martin Gould
Barry Hawkins 38-58 Stephen Maguire
Mark Allen 62-13 Kurt Maflin
Mark Williams 28-36 Michael Holt
Last 16 results
Mark Allen 92-15 Dominic Dale
Kurt Maflin 71-20 Thepchaiya Un-Nooh
Jack Lisowski 7-69 Michael Holt
Andrew Higginson 60-15 Liu Chuang
Nigel Bond 24-88 Martin Gould
Jimmy Robertson 8-106 Mark Williams
Barry Hawkins 43-39 Michael White
Dave Harold 32-1 Stephen Maguire