‘The Captain’ saw off Marco Fu in last week’s final in Berlin but crashed to a 4-2 third qualifying round defeat to Gerard Greene.
There was also a defeat for former world champion Peter Ebdon, who went down 4-3 to Pankaj Advani.
Neil Robertson and Shaun Murphy were among the star names to come through the qualifying rounds.
A new structure for the world ranking event meant that only the top four seeds (Ding Junhui, Mark Selby, Judd Trump and John Higgins) plus the top four Welsh players (Mark Williams, Matthew Stevens, Ryan Day and Dominic Dale) were guaranteed a place at the venue.
All other players had to go through the qualifiers in Sheffield.
Former World and Masters champion Robertson had a tough match against up-and-coming Welsh player Duane Jones, coming from 2-1 down to win 4-3. The Australian will now face Ian Burns in Newport.
Murphy scored a 4-2 win over Thepchiaya Un-Nooh to set up a match with India's Pankaj Advani, while Welsh amateur Gareth Allen will enjoy a dream debut at a ranking event venue on Monday at 1.30pm against four-time World Champion Higgins. The 24-year-old from Ewloe in Flintshire beat Rory McLeod 4-2.
Neath's Daniel Wells edged out former world number three James Wattana 4-3 and will now face a Welsh derby against Dale.
Ali Carter 2-4 Gerard Greene
Jamie Burnett 1-4 Craig Steadman
Stuart Bingham 4-2 Matthew Selt
Tom Ford 4-0 Justin Astley
Ricky Walden 4-2 Martin O'Donnell
Neil Robertson 4-3 Duane Jones
Ken Doherty 4-0 David Gilbert
Andrew Higginson 4-0 Adam Duffy
Mark Davis 2-4 Michael Wasley
Fergal O'Brien 4-1 Nigel Bond
Peter Ebdon 3-4 Pankaj Advani
Graeme Dott 4-1 Rod Lawler
Marcus Campbell 1-4 Anthony Hamilton
Shaun Murphy 4-2 Thepchaiya Un-Nooh
Stephen Maguire 4-3 Mark Joyce
Barry Hawkins 4-1 Zhang Anda
Michael Holt 0-4 Alan McManus
Joe Perry 4-1 Jimmy Robertson