Ryan Jones will return to captain Wales in their Six Nations championship match in France on Saturday after Sam Warburton was ruled out through injury.
Talismanic skipper Warburton has a stinger injury to nerves in his shoulder.
Jones has recovered from a thumb problem to lead Wales for a record 30th time as blindside flanker along with openside Justin Tipuric, who comes in for the benched Aaron Shingler.
In the only other change from the 30-22 home defeat by Ireland, the team's eighth loss in a row, Richard Hibbard replaces Matthew Rees at hooker.
"We didn't start the tournament the way we wanted to on the weekend but Saturday is a chance for us to go out and show what we can do," interim coach Rob Howley said.
"We know that we will have to start well and start the way we finished the game against Ireland. It's disappointing to have Sam ruled out but Ryan comes in as captain with a wealth of experience.
"Playing France in Paris is always a huge match but we have worked hard as a squad this week and want to deliver a performance we know we are capable of."
Centre Jamie Roberts will win his 50th cap.
Form and history is stacked against Wales, given they have claimed only three away wins at France's expense since 1975 and not beaten another playing Test-playing country for 11 months.
The current run of eight successive defeats is Wales' worst results sequence in 10 years, and their latest French assignment immediately follows Les Bleus' shock defeat to Italy.
"We still believe in ourselves, we still believe in our ability and the work we put in throughout the week," Wales full-back Leigh Halfpenny said.
"We are not in crisis. There is one game down and the tournament is still wide open.
"At the end of the day, we are the defending champions, and that means something. We have to go out and play like we are champions. We have to make sure we are putting the work in throughout the week and believe that every time we take to that pitch we are going to win. That is the attitude we have to have on Saturday."
France named their team on Thursday morning, with Frederic Michalak retaining his place at fly-half despite Les Bleus shock defeat in Rome last weekend.
Wales team: 15-Leigh Halfpenny, 14-Alex Cuthbert, 13-Jonathan Davies, 12-Jamie Roberts, 11-George North, 10-Dan Biggar, 9-Mike Phillips, 8-Toby Faletau, 7-Justin Tipuric, 6-Ryan Jones (captain)7, 5-Ian Evans, 4-Andrew Coombs, 3-Adam Jones, 2-Richard Hibbard, 1-Gethin Jenkins.
Replacements: 16-Ken Owens, 17-Paul James, 18-Craig Mitchell, 19-Lou Reed, 20-Aaron Shingler, 21-Lloyd Williams, 22-James Hook, 23-Scott Williams
France team: 15-Yoann Huget, 14-Wesley Fofana, 13-Mathieu Bastareaud, 12-Maxime Mermoz, 11-Benjamin Fall, 10-Frederic Michalak, 9-Maxime Machenaud, 8-Louis Picamoles, 7-Thierry Dusautoir (captain), 6-Fulgence Ouedraogo, 5-Yoann Maestri, 4-Jocelino Suta, 3-Nicolas Mas, 2-Dimitri Szarzewski, 1-Yannick Forestier
Replacements: 16-Benjamin Kayser, 17-Vincent Debaty, 18-Luc Ducalcon, 19-Romain Taofifenua, 20-Damien Chouly, 21-Morgan Parra, 22-François Trinh-Duc, 23-Florian Fritz