It is seven years since St Helens became the last team to follow up a Wembley triumph with victory in the Super League Grand Final, a feat which became tougher after the Challenge Cup final was moved from May to August.
However, Warrington went close last season when they lost in the Grand Final, just six weeks after winning at the national stadium, and Wane believes his side can go one better by adopting a different approach to the one followed by his predecessor in 2011.
Michael Maguire's team went into a rapid decline after their Wembley triumph two years ago, crashing to a 39-12 defeat at Warrington a week later before losing twice in the play-offs to St Helens.
"We made mistakes in 2011, there is no getting away from that," Wane said.
"The week after we went to Warrington and got butchered and from the first minute St Helens were always going to win because we were low on energy.
"We worked the lads hard but I'm going to give the lads a few days off this week and make sure they come next week very fresh for Leeds before we go into the play-offs.
"I am doing it my own way now, a different way and I hope it works."
Wane's way means a week off for the bulk of his Wembley-winning team as little-known youngsters Dom Manfredi, who will be making his debut, Lewis Tierney, Ryan Hampshire, Joe Burgess and George Williams step into their shoes for the rematch with Hull at the DW Stadium.
Huddersfield will clinch the league leaders' shield won by Wigan 12 months ago if Warrington fail to beat in-form St Helens in the derby at Langtree Park.
The Wolves are three points behind the Giants, who are at home to Wakefield on Sunday and go to Bradford in the final round.
In Friday's other game, Leeds host Catalan Dragons, who still need at least one win from their last two games to clinch a home tie in the play-offs.
The Dragons have never won at Headingley but Leeds coach Brian McDermott is expecting a difficult encounter.
"They're a tough bunch," he said. "We had a decent game against them at their place. It was physical and we're expecting the same.
"They are a physical bunch who play very direct. They try to run through you but our boys are ready for that."