Widespread reports have suggested as many as 14 Cronulla players have been looked into regarding the taking of banned substances. That led to suggestions the NRL clash between Shane Flanagan`s side and the Titans could be called off, but the NRL`s chief executive, Dave Smith, claimed on Thursday that would not be the case.
After a brief statement confirmed the game would go ahead, Smith said: "With the season kick-off just hours away we accept that the ongoing speculation around the ASADA investigation is causing incredible uncertainty for many in the game, particularly right now for Cronulla and its fans."
The statement continued: "As I have said from day one, the NRL is taking the ASADA investigation very seriously.
"It is an investigation that must be allowed to run its course and it is inappropriate for us to enter into speculation about what may be taking place.
"Let me make it very clear, however, the absolute majority of our players - the absolute majority - are doing the right thing. They are great ambassadors for the game, on and off the field as we will see at Allianz Stadium this evening.
"The Telstra Premiership is the closest and most exciting competition in sport and there is every reason for fans to look forward to a great year of Rugby League."
Cronulla also released a statement to confirm their co-operation with the ASADA investigation.
"Sharks fans and all rugby league supporters can be assured the club has been very proactive in fully co-operating with ASADA and taking other measures that prioritise the integrity of our club and the welfare of our playing group," the New South Wales club said.
"While there are strict boundaries around what we can say while the ASADA investigation is ongoing, fans should be assured that as soon as there is an opportunity to provide further information we will do so."