Wales kick off the tournament against Ireland in Cardiff on Saturday week. It is a reverse of last year's opener that Wales won at Dublin's Aviva Stadium. That success proved the springboard for an unbeaten Six Nations season as Wales landed their third Grand Slam in eight seasons.
And interim head coach Howley knows Wales will need to hit the heights again in the quest for a successful start, saying: "The one thing when we've played Ireland is they have been titanic struggles, fantastic games. The players seem to bring the best out of each other. It is a mouthwatering prospect the opening game."
He added: "Thankfully, the last couple of occasions we have come out on the right side of the scoreboard. Other times, we haven't.
"To come away with a win would be extra special, and we will need an extra-special performance against a very good side. That first game is a huge one. In terms of favourites and underdogs, having been involved in the Six Nations as a coach and player, each game is in isolation.
"As far as we are concerned we are looking at that first game against Ireland at the Millennium Stadium."
Captain Sam Warburton, meanwhile, believes Wales' loss of a winning formula is "easily recoverable" as they prepare to defend the Six Nations crown.
Wales have not beaten another Test-playing country since defeating France in last season's tournament finale. A run of seven successive defeats included four losses against Australia by a combined total of 13 points, while double Grand Slam-winning coach Warren Gatland will also not be at the Six Nations helm prior to leading the British and Irish Lions tour down under later this year.
"You don't become a bad side overnight, just like you don't become a good one," said Warburton. "It wasn't long ago we had some really good performances and really good wins. People are talking about Welsh rugby as if it has completely gone down to the pan.
"It is easily recoverable. We might have had seven losses in a row, but some of those have been really tight matches. Players appreciate it is the fine line of international rugby."