For more in-depth team news, quotes, facts and odds just click on the hyperlink of your choice.
All games KO at 19:45.
Mohamed Salah is not yet available but Fernando Torres (knee) and midfielder Marco van Ginkel (knee) are the only injury absentees for Chelsea; New signings Antonio Nocerino and Marco Borriello are both in contention to feature for West Ham.
Defender Carlos Cuellar has returned to light training after a long-term hip injury while full-back Andrea Dossena has shaken off an Achilles problem, although neither is likely to be involved; Striker Peter Odemwingie could make his Stoke debut at the Stadium of Light.
Aston Villa striker Gabriel Agbonlahor is likely to miss out with a foot injury; Nicolas Anelka is set to feature in Albion's first match since the Frenchman was charged by the Football Association over his 'quenelle' celebration.
Andros Townsend and Erik Lamela will miss out for Spurs, while Jan Vertonghen, Younes Kaboul and Sandro are back in training but remain doubts; Manchester City's top scorers Sergio Aguero and Alvaro Negredo could be back in tandem.