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Arsenal captain Thomas Vermaelen is available again following an ankle injury while Theo Walcott, Jack Wilshere and Santi Cazorla are poised to return to the starting line-up. Liverpool will welcome back fit-again trio Jose Reina, Jose Enrique and Glen Johnson.
Norwich defender Sebastien Bassong has recovered from a calf injury and is in line to face his former club, while Tottenham will have striker Jermain Defoe back from injury.
Everton are set to be without Kevin Mirallas and Seamus Coleman; Peter Odemwingie does not play as officially he has been given time off to see his wife and newborn son in hospital.
Emmanuel Frimpong is in line to make his Fulham debut after signing on loan from Arsenal. Meanwhile, West Ham striker Andy Carroll could return to the squad. The on-loan Liverpool forward has been missing since November with a knee problem.
Robin van Persie is set to lead a host of big names back into the United starting line-up. Skipper Nemanja Vidic and central-defensive partner Rio Ferdinand are also set to be included
Reading striker Jason Roberts will sit the match out while manager Brian McDermott has a concern over the fitness of Noel Hunt. Petr Cech has failed to recover from injury in time for Chelsea.