On-loan striker Lacina Traore is set to make his Everton debut. Long injury absentees Glenn Murray (knee) and Jerome Thomas (calf) came off the bench in Palace's defeat of West Brom and both are again likely to be substitutes at Goodison Park.
Central defender Fabricio Coloccini (knee), full-back Mathieu Debuchy (calf), midfielders Cheick Tiote (hamstring), Gabriel Obertan (knee) and Gael Bigirimana (ankle) and strikers Yoan Gouffran (muscle strain) and Papiss Cisse (back) are all doubts. Tottenham manager Tim Sherwood has no fresh injury concerns - with Sandro (calf) and Vlad Chriches (back) remaining sidelined.
Midfielder Mathieu Flamini serves the last of his three-match ban, while Aaron Ramsey (thigh) and deadline-day loan signing Kim Kallstrom (back) are not fit along with defender Thomas Vermaelen (calf); Phil Jones and Marouanne Fellaini are set to miss out for United.
Striker Marko Arnautovic remains doubtful with an ankle injury after missing Saturday's 2-2 draw at Southampton where fellow forward Oussama Assaidi picked up a hamstring knock late on. Hughes continues to be without Robert Huth with a knee injury. For the Swans, Jonjo Shelvey is set to miss out as he recovers from a hamstring injury. Forward Michu has a chance of featuring, but may not be risked as he closes in on a return from ankle surgery
New recruit Kostas Mitroglou misses out on making his Fulham debut due to injury. Brendan Rodgers may include Portugal Under-21 midfielder Joao Carlos Teixeira in the travelling party to freshen up the squad after training with the first team recently.