There were suggestions the defender could be rested after defying the knee injury suffered in last week's Champions League clash against Real Madrid to play 90 minutes at Chelsea on Sunday.
But the 26-year-old, who was outstanding as the champions drew 0-0 at Stamford Bridge, has not suffered any reaction that would prevent him playing again three days later.
City first-team coach David Platt said: "It's not a case of it being too much at all. Vinnie would have still been feeling the effects of the injury that he picked up last Wednesday in the game but he got through the game and got through it very well."
He added: "There were no after effects, he iced it straight afterwards as a precaution. We don't really have any concerns for him tomorrow night."
Kompany is therefore set to continue in central defence alongside 19-year-old Matija Nastasic, who is presently blocking fit-again England centre-back Joleon Lescott's route back into the team.
Nastasic, signed from Fiorentina on August's transfer deadline day, has started City's last seven matches. Lescott was out with a back injury for part of that sequence but has been available for the past three games.
Platt said: "That is testament to him (Nastasic). He has stepped in. The first couple of games he has had to get used to English football but he has done that very quickly.
"The really, really good performance - he has had several good ones, but the real one were it might have been a bit alien to him - was when we went down to West Ham.
"You knew the ball was coming in, they were hitting the diagonal balls towards Andy Carroll and I thought he acquitted himself exceptionally well.
"You get that a lot in the Premier League that you don't get in Serie A and it shows there is an old head on young shoulders to adapt to that."