Australia's captain curse has struck again with stand-in skipper Will Genia set to be ruled out for six months after rupturing his anterior cruciate ligament in Saturday's victory over South Africa in the Rugby Championship.
Scans have confirmed a tear in Genia's right knee, which he suffered 11 minutes from full-time in Australia's 26-19 win in Perth.
It is a cruel blow for the Wallabies who have already lost skipper James Horwill and his replacement David Pocock to injury.
It is understood Nathan Sharpe will take over the captaincy from Genia in what will be his third Test as skipper and the first time since 2005.
Melbourne Rebels number nine Nick Phipps is likely to take Genia's starting spot for next Saturday night's Test against Argentina on the Gold Coast.
Western Force half Brett Sheehan, who has not played for the Wallabies since 2008, has been drafted into the squad for the Pumas clash.
Genia was not the only injury concern out of the win over South Africa, with lock Sitaleki Timani also expected to miss the Argentina clash with a hamstring injury.
Timani suffered a grade one hamstring tear and is not expected to be risked, with either Rob Simmons or Kane Douglas to take his spot in the side.