The Argentinian has added Dejan Lovren, Victor Wanyama and Dani Osvaldo to his squad in recent months, running up a total transfer outlay of around B£36million.
But despite breaking the club's transfer record on two occasions this summer, after last year also splashing out on Gaston Ramirez and Jay Rodriguez, Saints fielded four products of their youth academy in Saturday's 1-0 win at West Brom.
Calum Chambers, Luke Shaw, James Ward-Prowse and Adam Lallana all started, as did Morgan Schneiderlin, who joined the south coast club as an 18-year-old.
Pochettino is keen to keep blooding such youngsters from the same academy that has produced the likes of Gareth Bale, Theo Walcott and Alex Oxlade-Chamberlain in recent times.
"I'm very happy with all the players who have come through the academy, we are very pleased about what we are doing in that sense," he said ahead of Saturday's game at home to Sunderland.
"It speaks volumes of the good job that [chairman] Nicola Cortese has been doing in terms of promoting the academy going up.
"I think you need a good mix between youth players and older, more experienced players. If you do have that equilibrium then it is going to bring a good energy to the club.
"It is tough because we have 22 to 23 players who are looking at getting in to the side."