The midfielder was booked for the fifth time this season during the 2-0 defeat at Sheffield Wednesday on Saturday and serves a one-match ban.
Boss Chris Powell told the club's official website: "I've lost Lawrie who has made a really big difference for us.
"We started off ever so well (against Wednesday) and created chances and he was at the hub of that. Sadly he will have a rest on Boxing Day."
But Powell will welcome back midfielder Dale Stephens, who has served his one-game ban.
Striker Ricardo Fuller, who scored Charlton's second in the 2-1 win at Portman Road earlier in the season, played the last half-hour at the weekend on his return from a hamstring injury and is pushing for a start.
Defenders Rhoys Wiggins (foot) and Cedric Evina (knee), midfielder Andy Hughes (Achilles) and striker Ade Azeez (hamstring) all remain sidelined.