United suffered a heavy 4-1 defeat in Moyes's first Manchester derby but has the chance to put the defeat behind him as they host Liverpool in the League Cup at Old Trafford on Wednesday.
However, asked whether Sunday's performance shocked him, Moyes replied: "Yes. It did. But when you have been a football manager for the amount of time I have you are always going to have shocks.
"I have had lots and I have no doubt there will be more in the future. That is the way football is."
With 10 players in his squad having less than the equivalent of a full game under their belts, changes are envisaged.
Not that Moyes is giving anything away.
"It does if I want to," he said, when asked whether the depth of his squad gives him the option to alter his line-up.
Moyes and Suarez have not always seen eye-to-eye, with the Scot accusing the striker of being a diver last season and the Liverpool man responding with a swallow dive in front of the Everton dug-out when he found the net in last season's derby.
"It means Liverpool have got a really good player," said Moyes.
"Does it change the complexion (of the game)? I am not looking at Liverpool too much. I just know the qualities of Luis Suarez are very good."
Van Persie sat out Sunday's 4-1 defeat at Manchester City with a groin injury.
And Moyes does not expect to have the Dutchman available until this weekend's Premier League encounter with West Brom at the earliest.
"I don't think he will play on Wednesday," said Moyes.
"He will have an outside chance for Saturday."