Wayne Rooney became the fourth player to reach the landmark figure with his brace in Tuesday's 4-2 Champions League win over Bayer Leverkusen.
It means he follows in the footsteps of Jack Rowley, Denis Law and Sir Bobby Charlton, who tops United's list of goalscorers with 249.
And Van Persie, who scored his sixth of the season with an acrobatic effort after Leverkusen skipper Simon Rofles had levelled Rooney's opener, couldn't speak more highly of his strike partner.
"I love to play alongside Wayne," said the Dutchman.
"He has a bit of everything. He can go up front, he can play in behind. He can play the short game and the longer game."
Rooney spent much of the summer at the centre of a protracted transfer wrangle.
Though he seemed certain to join Chelsea at one point, United stood firm, although Rooney has still not stated his desire to remain at Old Trafford in the long-term.
"Listen, I'm concentrating on my football as I have done all summer. I've put my head down, worked hard to get myself fit for the season. I'm pleased with the way I have come back and delighted that I am scoring goals," Rooney told ITV Sport.
When Rooney was then asked whether he had asked for a move, he snapped back: "Listen, I've just told you, I am concentrating on my football which I've been doing all summer."
With Antonio Valencia also getting on the scoresheet, United produced their best performance since the opening-day Barclays Premier League triumph at Swansea.
"I was very pleased with our team performance," said Van Persie.
"I thought we played well. When we had the ball we were very confident on it and everyone did their bit."