The Grecians had not won in front of their own supporters since November 6 and went into the game with only three victories on home soil all season but a John O'Flynn double sandwiched Scot Bennett's superb header as Exeter picked up three big points to move into the automatic promotion places.
"The win was built on a very determined group of players, which we have been for the last few home games, and I am really pleased with the way we stuck to the basics," said Tisdale. "We did the right things and got some really good goals to boot just to cap the result.
"All three goals were good goals and the corner (from which Bennett scored the second) was well worked. Jimmy Keohane was really selfless to set up the third and very few players would have done that in that situation and it showed what a classy player he is.
"When you have 11 players playing for the team, playing together and moving as a team trying to do their best and the little bits you have been working on start coming together, then you start to get results. As a result, we got a very valuable win.
"I am sure there were a few nerves in the second half because the players have been through some anxious times at home this season. We haven't given the home supporters much to cheer about, but I am sure we did today."
Southend boss Paul Sturrock felt his side were off the pace at both ends of the pitch.
He said: "We are very disappointed. I thought we had a lot of opportunities in the box and we didn't get on the end of them. We lost a bad goal two minutes before half-time and if we had scored first it might have been a completely different game.
"The second half was a weary-looking team trying to chase the game and it has cost us dear."