Winger Callum McManaman struck a fine opening goal in the 31st minute and Arouna Kone tapped home a second shortly before the break.
James McArthur struck a brilliant third goal early in the second half and although Huddersfield substitute Lee Novak headed home just after the hour, it was not enough to trouble Wigan, who emphatically underlined their superiority when Kone thundered home a fourth goal.
The visitors dominated early possession, but Huddersfield carved out their first chance when Alan Lee failed to keep his header on target from Calum Woods' cross.
Wigan's pressure, however, yielded rewards as McArthur swivelled on the spot and sent a fine ball in behind Huddersfield right-back Jack Hunt to set McManaman free. The Wigan winger raced into the penalty area before dinking a cool finish over sprawling home goalkeeper Alex Smithies.
Wigan doubled their lead five minutes before half-time as McManaman's pace sent him clear of Hunt and his excellent low cross was met by Jordi Gomez, whose goalbound shot was blocked only for Kone to flick home the rebound at the far post.
Maynor Figueroa unleashed a shot into the side-netting before McManaman and McArthur combined on the left again to put the tie beyond doubt in the 56th minute. The latter arrowed an unstoppable shot from the edge of the area into the top corner.
But Huddersfield did not lie down and Novak lifted home spirits when heading home Calum Woods' pinpoint cross six minutes later.
The fourth goal came when Kone pounced on a loose ball 25 yards from goal in the 89th minute and, after evading the covering defence, crashed home a right-footed shot from just inside the area.