Andre Villas-Boas' Spurs side will be guaranteed of avoiding Spanish sides Valencia and Sevilla, as well as French club Lyon.
However, Wigan and Swansea are both expected to be among the pot of third seeds.
Spurs' 3-0 win over Dinamo Tblisi followed a 5-0 first-leg victory and has established the north London side as one of the favourites for the competition.
Wigan qualified for the group stage automatically as FA Cup winners while Swansea sealed their place in the group stage courtesy of a 6-3 aggregate win over Petrolul Ploiesti.
The clubs from the English leagues are guaranteed to avoid each other in the draw for the Europa League groups here in Monaco.
The top two in each group will go into a knockout round of 32 clubs including the eight sides that finish third in the Champions League groups.