Rovers recorded a memorable 1-0 FA Cup win over Arsenal at the weekend, although Appleton could look to rest aching limbs and bring recent loan recruits David Bentley, Karim Rekik and DJ Campbell into contention.
Former Manchester United forward Josh King is expected to remain sidelined due to a hamstring problem, but there is more positive news surrounding the club's other injury absentees.
Republic of Ireland international striker Leon Best is set to play for Blackburn's second-string against Sunderland on Monday evening - his first action since suffering knee ligament damage in a pre-season friendly with AEK Athens.
Dickson Etuhu (knee) and Adam Henley (hamstring) are due to step up their own rehabilitation alongside Best but none of the trio are in contention to feature at the KC Stadium.
Experienced duo Paul Robinson (back) and David Dunn (calf) remain on the sidelines.