Wayne Rooney misses out after suffering a nasty gash to his head in an accidental training ground collision with Phil Jones on Saturday.
"It is bad," said Manchester United manager David Moyes.
"It's right down the middle of his forehead where it takes a wee while to heal.
"It was just a boot, Phil Jones caught him right down the middle of his forehead. It will probably three weeks."
If that was not bad enough, Jones and Johnson were both forced out of Sunday afternoon's clash at Anfield.
Jones went off after landing awkwardly following an aerial challenge, while Johnson left the stadium of crutches after a crunching tackle with Patrice Evra.
"It's a bad twist to his ankle," said Moyes of Jones, whilst Johnson himself hardly offered good news over his fitness.
"My ankle feels bad at the mo but i have a scan tom morning. So fingers crossed," the full-back said on Twitter.
Hodgson acted swiftly to cover for injuries as he called former Tottenham defender Caulker into the squad.
"England have called up Steven Caulker following the withdrawal of three players from Roy Hodgson's squad due to injury," said an FA statement.
Caulker has one England cap to his name, having started and scored against Sweden in Stockholm in November 2012.
And it also seems match-winner Daniel Sturridge is a doubt with a groin injury.
"We just need to assess it," said Rodgers.
"We weren't sure whether he was going to make it but he put himself out there so we will see.
"We need to think of Liverpool first. The priority will be with Liverpool, if he is ok, then he will go."
Jack Wilshere was then forced out of the north London derby at the Emirates Stadium.
However, concerns over the midfielder's troublesome ankle were dispelled, with initial claims the problem was an upset stomach.