The winger was ruled out of the Valiants' last game, a 1-1 draw at Cheltenham, through suspension, but is available to make an immediate return to the starting line-up at the New York Stadium.
The 24-year-old was due to play against AFC Wimbledon on Saturday, but with the game being postponed due to a waterlogged pitch, Myrie-Williams has been made to wait a further four days for his comeback.
Cheltenham's 4-1 defeat to Rochdale on Friday night means Micky Adams' men stay in second place in the npower League Two table, despite the postponement.
The Vale Park boss has a fully-fit squad to choose from as his side attempt to get back to winning ways after four games without a victory.
Louis Dodds marked his return to the side with an equalising goal against the Robins, and is set to keeping his starting place.