"The thing that annoys me most is that I won't have Pazzini available," said coach Massimiliano Allegri at Friday's pre-match news conference.
The striker is out of action until at least late October with a knee injury.
Allegri's injury woes were exacerbated on Tuesday night when Boateng and De Jong both left the field injured during his side's 1-1 draw at PSV Eindhoven in the first leg of their Champions League playoff. Muntari is suspended.
Milan finished third in Serie A last season.