The Wigan midfielder played in the 2-0 Community Shield defeat by Manchester United at the national stadium on Sunday and then turned his attention to returning in midweek, along with over 24,000 of the Tartan Army, for a challenge match which is more keenly-awaited north of the border than down south.
McArthur, 25, remembers well the night Don Hutchison scored in the 1-0 win over England at Wembley when Scotland last visited in November 1999, although it was not enough to save the Scots from losing 2-1 on aggregate to the Auld Enemy in the Euro 2000 play-off.
The former Hamilton player revealed he is hoping for another victory to write his name in the history books and inspire another generation of aspiring Scottish footballers.
"It is a fixture the fans will remember for a number of years and it is a chance to make yourself a legend," he said.
"I still hold the fixture in high esteem. I was so excited when I heard the fixture was coming up and I'm hopefully playing.
"It is the biggest game for Scotland in a number of years even though it is deemed a friendly.
"We don't see it as a friendly and the fans won't see it as a friendly and we will be looking to win the match.
"When you look at Don Hutchison scoring the winner, it is one of those games you remember as a kid and all through your life.
"I was on the bus coming back from one of my (youth) games but I was celebrating on the bus.
"Hopefully we can do that on Wednesday night, give some kids memories for the rest of their lives.
"The Tartan Army will be out in force. I think they have bought around 24,000 tickets and I'm sure there will be more down here.
"They are a great support and they will get right behind us and we want to do it for them."
McArthur's fellow Wigan player Shaun Maloney concurred with the magnitude of the game as far as Scotland are concerned.
The former Celtic and Aston Villa player said: "I think it will be as big as anything I have played in.
"These fixtures don't happen very often but to play against England at Wembley is the most important international game I have played in and I will imagine it will be on a par with anything I have played in club football.
"So that's what it means to us and I imagine the majority of the country.
"I understand it is a friendly and some of their players will play 45 minutes and things like that but for us it will mean the world."
Scotland go into the game on the back of a 1-0 World Cup qualifying win in Croatia in June and although they have no chance of playing in the finals in Brazil next summer, Maloney believes the result will boost the Scots as they prepare for Wembley.
The Aberdonian, though, insists those same heights will have to be reached if they are to get a result against England.
"In the current rankings and looking at our own qualifying group there is a decent margin between us and England," he said.
"I think you could maybe compare it to us playing Croatia.
"We will certainly be going in as underdogs on Wednesday but hoping that we can get the result.
"We didn't play Croatia off the park, we worked hard and were very organised, got a goal and defended pretty well after that and if we are to get a decent result against England it will be something similar in that game."